Plant Transcription Factor Database
Previous version: v3.0
Solanum lycopersicum
M-type_MADS Family
Species TF ID Description
Solyc00g179240.1.1M-type_MADS family protein
Solyc01g010300.1.1M-type_MADS family protein
Solyc01g060300.1.1M-type_MADS family protein
Solyc01g060310.1.1M-type_MADS family protein
Solyc01g066500.1.1M-type_MADS family protein
Solyc01g066730.2.1M-type_MADS family protein
Solyc01g097850.1.1M-type_MADS family protein
Solyc01g098050.1.1M-type_MADS family protein
Solyc01g098060.1.1M-type_MADS family protein
Solyc01g098070.1.1M-type_MADS family protein
Solyc01g102260.2.1M-type_MADS family protein
Solyc01g103550.1.1M-type_MADS family protein
Solyc01g103870.1.1M-type_MADS family protein
Solyc01g106170.2.1M-type_MADS family protein
Solyc01g106700.2.1M-type_MADS family protein
Solyc01g106710.1.1M-type_MADS family protein
Solyc01g106720.1.1M-type_MADS family protein
Solyc01g106730.1.1M-type_MADS family protein
Solyc02g032000.1.1M-type_MADS family protein
Solyc03g007020.1.1M-type_MADS family protein
Solyc03g034260.1.1M-type_MADS family protein
Solyc03g062820.1.1M-type_MADS family protein
Solyc03g115910.1.1M-type_MADS family protein
Solyc03g119680.1.1M-type_MADS family protein
Solyc04g025030.1.1M-type_MADS family protein
Solyc04g025050.1.1M-type_MADS family protein
Solyc04g025110.1.1M-type_MADS family protein
Solyc04g025970.1.1M-type_MADS family protein
Solyc04g047870.1.1M-type_MADS family protein
Solyc04g056550.1.1M-type_MADS family protein
Solyc04g056740.1.1M-type_MADS family protein
Solyc04g064860.1.1M-type_MADS family protein
Solyc04g076680.2.1M-type_MADS family protein
Solyc05g013370.1.1M-type_MADS family protein
Solyc05g015730.1.1M-type_MADS family protein
Solyc05g051830.2.1M-type_MADS family protein
Solyc06g033820.1.1M-type_MADS family protein
Solyc06g033830.1.1M-type_MADS family protein
Solyc06g035570.1.1M-type_MADS family protein
Solyc06g048380.1.1M-type_MADS family protein
Solyc06g054680.1.1M-type_MADS family protein
Solyc06g059780.1.1M-type_MADS family protein
Solyc06g071300.1.1M-type_MADS family protein
Solyc07g052700.2.1M-type_MADS family protein
Solyc09g061950.1.1M-type_MADS family protein
Solyc10g012180.1.1M-type_MADS family protein
Solyc10g012200.1.1M-type_MADS family protein
Solyc10g012380.1.1M-type_MADS family protein
Solyc10g012390.1.1M-type_MADS family protein
Solyc10g017640.1.1M-type_MADS family protein
Solyc10g018070.1.1M-type_MADS family protein
Solyc10g018080.1.1M-type_MADS family protein
Solyc10g018110.1.1M-type_MADS family protein
Solyc10g050900.1.1M-type_MADS family protein
Solyc10g050940.1.1M-type_MADS family protein
Solyc10g050950.1.1M-type_MADS family protein
Solyc11g020320.1.1M-type_MADS family protein
Solyc11g020620.1.1M-type_MADS family protein
Solyc11g020660.1.1M-type_MADS family protein
Solyc11g069770.1.1M-type_MADS family protein
Solyc12g005210.1.1M-type_MADS family protein
Solyc12g016150.1.1M-type_MADS family protein
Solyc12g016170.1.1M-type_MADS family protein
Solyc12g016180.1.1M-type_MADS family protein
Solyc12g017300.1.1M-type_MADS family protein
Solyc12g087820.1.1M-type_MADS family protein
Solyc12g088080.1.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513